Scientists at NCI generate largest data set of cancer-related genetic variations | Science Codex


See on Scoop.itData Nerd’s Corner

PHILADELPHIA — Scientists at the National Cancer Institute (NCI) have generated a data set of cancer-specific genetic variations and are making these data available to the research community, according to a study published in Cancer Research, a journal…

Carla Gentry CSPO‘s insight:

The NCI-60 human cancer cell line panel is used extensively by cancer researchers to discover novel anti-cancer drugs. To conduct whole-exome sequencing, Pommier and his NCI team extracted DNA from the 60 different cell lines, which represent cancers of the lung, colon, brain, ovary, breast, prostate and kidney, as well as leukemia and melanoma, and cataloged the genetic coding variants for the entire human genome. The genetic variations identified were of two types: type I variants corresponding to variants found in the normal population, and type II variants, which are cancer-specific.

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